20 pieces
Injectable
500mg, 1g
Cefotaxime® Cefotaxime
Injection vial 500 mg and 1 g
General instructions:
This medicine has been prescribed for your current illness. Do not use it in similar cases or recommend it to others.
Before using this medicine, consult your doctor in the following cases:
If you have a history of allergy to penicillins, cephalosporins, penicillin-like drugs, penicillamine, preservatives and dyes.
If you have kidney, liver, stomach and intestinal diseases.
If you are taking any other medicine.
Use of this medicine during pregnancy and breastfeeding should be under the advice of a specialist doctor.
Warnings:
If you experience any allergic reaction to the medicine, stop taking the medicine. In severe allergies, immediate medical action is required.
Take the medicine at regular intervals. Complete the course of treatment.
If the symptoms of the disease do not improve, inform your doctor.
If diarrhea occurs, contact your doctor and avoid self-medication with antidiarrheal drugs.
This drug causes false positive results in urine sugar. Therefore, inform your doctor before changing the dosage of your antidiabetic drug.
This product contains about 2.2 milliequivalents of sodium per gram. Therefore, its administration to patients who have sodium restrictions should be done with caution.
Dosage:
The doctor determines the amount of the drug. The usual dosage of the drug is as follows:
Adults:
For gonorrhea and anal infections in women, 500 mg as a single dose by intramuscular injection.
For gonorrhea and anal infections in men, 1 gram as a single dose by intramuscular injection.
Surgical prophylaxis: 1 gram intravenously or intramuscularly half an hour to 1 hour before surgery.
Cesarean section: 1 gram intravenously when the umbilical cord is clamped. Then 1 gram intravenously or intramuscularly 6 and 12 hours after the first dose.
In septicemia: 2 grams intravenously every 6 to 8 hours.
The maximum dose in adults is 12 grams per day.
Children:
In bacterial infections:
Infant less than 1 week: 50 mg per kg of body weight intravenously every 12 hours.
Infant 1 to 4 weeks: 50 mg per kg of body weight intravenously every 8 hours.
Infant and children 1 month and older weighing less than 50 kg: 8.3 to 30 mg per kg of body weight intravenously every 4 hours or 12.5 to 45 mg per kg of body weight intravenously every 6 hours.
Children weighing 50 kg and more are prescribed as adults.
How to use the drug:
For intramuscular injection, add 2 and 3 ml of sterile water for injection to the 500 mg and 1 gram vials, respectively, and shake well until completely dissolved.
For intravenous injection, add 10 mL of sterile water for injection to each 500 mg or 1 g vial and shake well to dissolve completely.
Intravenous solutions should be infused over 3 to 5 minutes.
For intravenous infusion: Dilute the initial concentration with 50-100 mL of 0.9% sodium chloride injection or 5% dextrose injection. Intravenous infusion should be performed over 20 to 30 minutes.
After the powder has dissolved, if foreign particles or turbidity are observed, do not inject.
The color of the solution varies from pale yellow to light amber. Do not use if the solution changes color and darkens.
Drug interactions:
Avoid mixing cefotaxime with aminoglycosides such as gentamicin for intravenous injection. If simultaneous administration is required, these drugs should be injected at two separate sites.
Side effects:
Every drug may cause some unwanted effects along with the desired therapeutic effect. Given that not all of these effects are seen in one person. Consult your doctor if any of the following side effects occur:
Black stools, chest pain, cold, cough, fever, itchy skin, redness of the skin, sore throat, fatigue, general and unusual weakness, abdominal pain and cramps, diarrhea, hives, skin rash, joint pain, nausea and vomiting, shortness of breath and irregular breathing, headache and sore tongue and throat.
Storage conditions:
Store the dry product at a temperature below 30 degrees Celsius, away from light and moisture.
Avoid using expired medicine.
Keep the medicine out of the reach of children.
Dosage Forms and Packaging:
Cefotaxime 500 mg injection vial: Each vial contains 500 mg of cefotaxime (as sodium) and is packaged in a box of 20 with a leaflet.
Cefotaxime 1 g injection vial: Each vial contains 1 g of cefotaxime (as sodium) and is packaged in a box of 20 with a leaflet.
This drug is used in the treatment of infections caused by gram-positive and gram-negative bacteria susceptible to the drug, including bone and joint infections, gonorrhea, urinary tract infections, and also as a prophylaxis of infection before surgery.
Cefotaxime inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs), which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall and ultimately cell wall biosynthesis.
Bacteria are eventually lysed due to the continuous activity of cell wall autolytic enzymes (autolysins and murine hydrolases) while cell wall assembly is inhibited.
Cefotaxime is active in the presence of some beta-lactamases, penicillinases, and cephalosporinases in gram-negative and gram-positive bacteria. Enterococci species may be inherently resistant to cefotaxime. Most extended-spectrum beta-lactamase (ESBL) producers and carbapenemase producers are resistant to cefotaxime.
Serum concentrations peak half an hour after intramuscular injection. The half-life of the drug is 1 hour, which may increase to 3 hours in cases of renal impairment. 50-60% of the drug is excreted by glomerular filtration.
The risk of nephrotoxicity increases when cephalosporins are used concomitantly with aminoglycosides or vancomycin. The anticoagulant effect of warfarin may be increased when these drugs are used concomitantly.
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