100 Pieces
Oral
250mg , 500mg
Scientific Drug Guide for Patients
This medication has been prescribed to treat your current condition, so do not use it in similar cases or recommend it to others.
General Instructions
Before using this medication, consult your doctor in the following cases:
If you have a history of allergies to penicillin and cephalosporin drugs, or other drugs, foods, preservatives, and dyes.
If you are taking painkillers, thyroid, anticoagulants, birth control pills, and any other antibiotics (such as chloramphenicol, erythromycin, sulfonamides, tetracycline, etc.)
If you suffer from asthma and allergies, congestive heart disease, kidney disease, mononucleosis,
Phenylketonuria, and recurrent abdominal pain.
Use during pregnancy and breastfeeding
This medication is not harmful during pregnancy, but it should be used under the supervision of a specialist.
The use of the drug during breastfeeding should be under the supervision of a specialist.
Warnings
Amoxicillin suspension contains phenylalanine, which is prohibited for use in patients with phenylketonuria.
If the disease does not improve after a few days of taking the drug, inform your doctor.
To completely eliminate the infection, it is necessary to comply with the duration of the treatment course even if improvement is observed.
To observe a better therapeutic effect, it is recommended to take the drug at the prescribed time.
In case of severe diarrhea, contact your doctor and avoid taking antidiarrheal drugs in these conditions without
consulting your doctor.
Taking this drug may cause disturbances in urine sugar measurement tests, so consult your doctor before changing your diet or changing the dosage of blood sugar-lowering drugs.
Take the drug on a full or empty stomach with a glass of water or fruit juice.
Dosage and correct way to use the medicine
The dosage of each medicine is determined by the doctor, but the usual dosage of this medicine is as follows:
Capsule:
In adults and children over 40 kg: For bacterial infections, 250 to 500 mg every 8 hours or 500 to 875 mg every 12 hours, depending on the type and severity of the infection.
For peptic ulcers (associated with Helicobacter pylori), 1000 mg two or three times a day.
Suspension:
In adults and children over 40 kg: The dosage is the same as the capsule dosage.
In infants over 3 months and children weighing less than 40 kg: For bacterial infections, 6.7 to 13.3 mg per kilogram of body weight every 8 hours or 12.5 to 22.5 mg per kilogram of body weight every 12 hours.
In infants less than 3 months: For bacterial infections, a maximum of 15 mg per kilogram of body weight
Every 12 hours.
How to prepare the suspension
Shake the bottle before preparing the suspension to disperse the powder. Then add boiled and cooled water to the mark in two stages and shake well.
Shake the bottle well before each use.
Wash the measuring cup before and after each use.
Close the bottle tightly after each use.
Missed dose
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for the next dose, take the medicine as usual and do not double the dose.
Side effects
Along with the desired therapeutic effects, any medicine may cause some unwanted effects, although not all of these side effects may appear in one person, but if they do, they require medical attention.
Side effects that require immediate discontinuation of the drug and immediate contact with a doctor: irregular and rapid breathing, fever, pain, joints, dizziness, fainting, sudden syncope, swelling of the face, redness, peeling of the skin, rash, hives and itching.
Side effects that require medical attention:
Abdominal cramps with severe pain, painful abdominal cramps, seizures, decreased urine output, severe watery diarrhea
(may be accompanied by blood), depression, nausea and vomiting, sore throat and fever, unusual subcutaneous bleeding and yellowing of the eyes or skin (symptoms such as abdominal cramps with severe pain and severe watery diarrhea may also be observed for several weeks after stopping the drug.)
Side effects that disappear over time and as the body adapts to the drug, but require medical attention if they persist or worsen: moderate diarrhea, headache, mouth and tongue pain, vaginal itching and discharge, white spots in the mouth or on the tongue.
Poisoning
In case of accidental overdose, transfer the patient to a medical facility.
Storage conditions
Avoid using expired medication.
Keep the medication out of reach of children.
Store the dry powder for suspension at a temperature below 30°C and away from moisture.
The prepared suspension can be stored for up to 7 days at room temperature or 14 days in the refrigerator. After this period, discard the remainder.
Store capsules at a temperature below 30°C.
Powder for oral suspension:
200 and 400 mg of amoxicillin (as trihydrate) in 5 ml
125 and 500 mg of amoxicillin (as trihydrate) in 5 ml
Capsules:
250 and 500 mg of amoxicillin (as trihydrate)
Amoxicillin is one of the most widely used antibiotics in the world. Its easy availability and broad spectrum of antibacterial activity have made it a popular choice for treating many common infections such as pharyngitis, respiratory tract infections, urinary tract infections, skin and soft tissue infections, and dental infections, etc. in adults and children. Given the high value of this drug in controlling infections, in order to maintain its effectiveness and protect it against microbial resistance, it is necessary to give special importance to its rational administration and use. Amoxicillin can also be used to prevent infection in some cases such as rheumatic fever.
Amoxicillin acts by inhibiting the synthesis of bacterial cell walls, so that the bacteria will not be able to maintain their structure and continue to grow.
1. Absorption:
• Oral:
Amoxicillin is well absorbed from the gastrointestinal tract.
• Absorption: Approximately 74-92% of the oral dose.
• Time to peak plasma concentration (Tmax): 1-2 hours after administration.
• Food effect: Food has no significant effect on absorption, but may reduce gastrointestinal side effects.
2. Distribution:
• Volume of distribution (Vd): Approximately 0.3 L/kg.
• Amoxicillin is widely distributed in body fluids and tissues, but its entry into cerebrospinal fluid (CSF) is limited, except in cases of inflammation of the meninges.
• Plasma protein binding: Approximately 17-20%.
3. Metabolism:
Amoxicillin is very poorly metabolized in the liver and is largely excreted unchanged.
• Less than 30% of the administered dose is converted to inactive metabolites.
4. Elimination:
• The main route of excretion: mainly via the urine.
• About 60-70% of the oral dose is excreted unchanged in the urine.
• Small amounts are excreted via the bile.
5. Elimination Half-Life:
• In healthy subjects: about 1-1.5 hours.
• In renal failure: the half-life may be significantly increased.
1. Antacids:
• Interaction: Drugs used to reduce stomach acid (such as tocopherol or drugs containing magnesium and aluminum) can reduce the absorption of amoxicillin.
• Result: The effect of amoxicillin may be reduced and the treatment may be slower.
• Recommendation: It is best to take amoxicillin at least 2 hours before or after taking antacids.
2. Blood thinners (such as warfarin):
• Interaction: Amoxicillin can enhance the effect of drugs used to thin the blood (such as warfarin).
• Result: This can increase the risk of bleeding.
• Recommendation: If used simultaneously, your doctor may need to monitor your bleeding and your dosage more closely.
3. Probenecid:
• Interaction: This drug, which is commonly prescribed to treat gout, can reduce the excretion of amoxicillin.
• Result: Amoxicillin levels in the body increase.
• Recommendation: Amoxicillin dosage may need to be adjusted if taken simultaneously.
4. Methotrexate:
• Interaction: Amoxicillin may increase methotrexate levels in the body.
• Result: This can increase the risk of methotrexate side effects.
• Recommendation: Close monitoring of methotrexate levels and consultation with a doctor is essential.
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