20 pieces
Oral
120mg
Orlistat® (Orlistat)
120 mg capsule
This medicine has been prescribed for your current condition. Therefore, do not use it in similar cases or recommend its use to others.
General instructions:
If you have a history of allergies to this medicine, foods, food additives, dyes, etc.
If you have chronic malabsorption syndrome, liver disorder (cholestasis), hypothyroidism, anorexia and bulimia
If you are taking antiepileptic drugs, anticoagulants (warfarin), amiodarone and anti-HIV drugs
Use during pregnancy and breastfeeding:
The use of this medicine is prohibited during pregnancy and its use is not recommended during breastfeeding.
Warnings:
The use of Orlistat may be associated with the formation of kidney stones in patients with chronic kidney disease. If you develop kidney stones, inform your doctor.
The simultaneous use of this medicine with cyclosporine and acarbose is not recommended.
If a meal is missed or a low-fat meal is consumed, there is no need to take the medication at that meal.
It is recommended to use a method of contraception other than oral contraceptives to prevent possible failure that may occur in case of severe diarrhea.
To increase the effectiveness of the drug and lose weight, it is necessary to control the diet and avoid excessive fat intake.
Daily fat intake should be evenly distributed over three main meals, because if orlistat is taken with a very high-fat meal, the risk of gastrointestinal complications may increase.
Orlistat reduces the absorption of some fat-soluble nutrients, especially beta-carotene and vitamin E. Therefore, the diet should be balanced in terms of food and rich in fruits and vegetables.
Orlistat may reduce the absorption of vitamins needed by the body, so taking a multivitamin is recommended during the course of taking the medication.
In patients with diabetes, weight loss with orlistat may lead to improvement in the disease and the attending physician may change the dose of oral diabetes medications or insulin.
Orlistat prevents fat absorption, so this medicine should be taken with food and 1 hour after it.
Dosage and method of use of the medicine:
The amount of medicine is determined by the attending physician for each patient. However, the usual dosage of the medicine is as follows:
For the treatment of obesity
Adults: 120 mg three times a day with fatty food
Orlistat capsules can be taken immediately before, during or up to one hour after a meal.
If you forget to take a dose of the medicine, take it as soon as you remember, but if it is almost time for the next dose, skip it and avoid doubling the dose.
Orlistat is not recommended for children.
Side effects:
In addition to the desired therapeutic effects, any medicine may have some unwanted side effects. If any of the following side effects occur, inform your doctor.
Important side effects that require medical attention if they occur: Anaphylactic reactions, sudden allergic reactions such as swelling of the face, tongue, shortness of breath, angioedema
More common: Body aches, fever and chills, headache, cough, sore throat, nasal congestion, runny nose, sneezing
Less common: Chest tightness, breathing problems, wheezing, gum and tooth problems
Rare: Infectious diarrhea, hearing changes, ear pain, dark or bloody urine, frequent urination, difficulty and pain during urination
The following side effects may also occur that do not require medical intervention. These may go away on their own with continued use of the medication, but if they persist or become bothersome, you should see a doctor.
More common: Inability to control stool, increased bowel movements, greasy stools, greasy stains on underwear, bloating with cramps
Less common: Anxiety, back pain, changes in menstruation, anal pain and discomfort
Rare: Muscle and joint pain, dizziness, dry skin, insomnia, nausea and vomiting, skin rash
Storage conditions:
Store the product at a temperature below 30 degrees Celsius, away from light and moisture.
Keep the medicine out of the reach of children.
Do not use the medicine after the expiration date printed on the carton.
After use, do not throw any medicine in the sewer or non-recyclable waste to protect the environment.
Dosage forms and packaging:
This medicine is produced and supplied in capsules containing 120 mg of orlistat and in boxes of 20 by Afashimi Pharmaceutical Company.
Orlistat is the most widely used anti-obesity drug with the fewest side effects. This drug has been introduced as a weight loss, weight maintenance, and weight gain prevention drug by potently and reversiblely inhibiting pancreatic lipase and preventing the absorption of dietary fat. Unlike other weight loss drugs such as phentermine, which reduces appetite by stimulating the central nervous system; Orlistat acts locally in the gastrointestinal tract and reduces the absorption of dietary fat by up to 30%.
Orlistat is used as a treatment for obesity, and it is expected that a person will lose 5 to 10% of their initial weight or 5 to 9 kilograms per year. At the same time, the response of individuals to Orlistat is not the same; for example, in people with type 2 diabetes, the weight loss process is slower and requires long-term use of the drug. On the other hand, in these people, due to the risk of mortality from macrovascular problems, in addition to weight loss, improving the cardiovascular profile such as blood lipids and blood pressure and improving lifestyle are also considered therapeutic goals. Studies have shown that taking orlistat for 6 to 12 months causes a significant reduction in blood cholesterol.
Absorption: The absorption of the drug after oral administration is very low and reaches maximum plasma concentration within 6 to 8 hours. The onset of action of orlistat is 24 hours after administration and the bioavailability of the drug is reported to be 5%.
Metabolism: Orlistat is metabolized in the intestinal wall and produces inactive metabolites M1 and M3.
Excretion: 95 to 97% of orlistat is excreted in the feces and less than 3% in the urine. The elimination half-life of the drug is about 1 to 2 hours.
General Interaction Profile:
– Decreased absorption of fat-soluble substances
• Use caution when co-administering with oral medications with a narrow therapeutic window. Orlistat may decrease the absorption of some oral medications.
Interactions Category X (Avoid):
Triheptaneion
Drugs reduced by Orlistat:
Amiodarone, antiepileptic drugs, antiretroviral drugs, cyclosporine (systemic), levothyroxine, multivitamin/fluoride (containing vitamins A, D, and E), multivitamin/mineral (containing vitamins A, D, E, K, folate, and iron), multivitamin/mineral (containing vitamins A, E, and no iron), paricalcitol, propafenone, sincalide, triheptaneion, vitamin D analogs, fat-soluble vitamins
Drugs enhanced by Orlistat:
Vitamin K antagonists
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