Vial Afazol® (Cefazolin)

Afazol®

Cefazolin powder for injection 250, 500 and 1000 mg

General patient instructions:

This medicine has been prescribed to treat your current condition, so do not use it in similar cases or recommend it to others.

Before taking this medicine, consult your doctor in the following cases:

If you have a history of allergy to penicillin and cephalosporin drugs, other drugs, foods, preservatives and dyes.

If you are taking drugs containing alcohol, aminoglycosides, antacids, ranitidine and other histamine H2 receptor antagonists, anticoagulants, thrombolytic compounds, diuretics and iron.

If you are pregnant and breastfeeding

If you have a history of colitis, digestive disorders, bleeding disorders, liver failure and kidney failure.

Use in pregnancy and lactation:

Pregnancy: This drug is classified as FDA Category B. Use of this drug during pregnancy should be under the advice of a specialist.

Lactation: Cefazolin is secreted in small amounts in breast milk. Use of this drug during lactation should be under the advice of a specialist.

Warnings:

People with a history of allergy to penicillin, penicillin derivatives, or penicillamine may also be sensitive to cefazolin. Cases of severe allergy and even anaphylactic reactions have been reported in penicillin-sensitive people after administration of cefazolin.

If no improvement in symptoms is observed within a few days after use, inform your doctor.

Taking this drug may interfere with blood sugar measurement tests, so inform your doctor before changing the dose of antidiabetic medication.

In cases of severe diarrhea, consult your doctor before taking any medication.

Intravenous infusion should be administered over 30 minutes.

Intramuscular injection should be given deep into a large muscle.

Each gram of this product contains approximately 48 mg of sodium, so this medication should be administered with caution to patients on a salt restriction.

Dosage and method of administration:

The dosage of each drug is determined by the doctor, but the usual dosage of this drug is as follows:

In the prevention of infection before surgery: 1 gram, half to one hour before the start of surgery, 500 mg to 1 gram during surgery, and 500 mg to 1 gram every 6-8 hours to 24 hours after surgery by intramuscular or intravenous injection.

In the treatment of other infections:

In mild infections, 250 to 500 mg every 8 hours by intramuscular or intravenous injection.

In severe infections, 500 mg to 1 gram every 6-8 hours by intramuscular or intravenous injection.

In very severe infections, 1 to 1.5 grams every 6 hours by intramuscular or intravenous injection.

Children and infants older than one month: 25-6.25 mg per kilogram of body weight every 6 hours or 33.3-8.3 mg per kilogram of body weight every 8 hours by intramuscular or intravenous injection.

Infants less than one month old: 20 mg per kg of body weight every 8-12 hours by intravenous injection.

Missed dose:

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, take the next dose as scheduled and do not double the dose.

Preparing vials for injection:

Intramuscular injection: To prepare a solution of cefazolin for intramuscular injection, add 2 ml of sterile water for injection to each 250 or 500 mg vial and 2.5 ml to each 1 g vial.

Slow intravenous injection: For intravenous injection, follow the instructions above for the 250 mg, 500 mg, and 1 g vials. Then add 5-10 ml of sterile water for injection to the vial and inject the resulting solution slowly into the vein over 3-5 minutes.

Intravenous infusion: For intravenous infusion, dilute the resulting solution for slow intravenous injection with 50-100 ml of 5% dextrose solution for injection or 0.9% sodium chloride solution for injection.

Side effects:

In addition to the desired therapeutic effect, any drug may cause some unwanted effects, although not all of these effects may occur in the same person.

Side effects that require medical attention: eosinophilia, hypersensitivity reactions, agranulocytosis

Side effects that require medical attention if they persist or worsen during treatment: gastrointestinal disorders, headache, oral and vaginal candidiasis, dizziness, drug fever.

Side effects that indicate the possibility of pseudomembranous colitis and require medical attention if they occur after discontinuation of the drug: severe abdominal pain or cramps, severe and watery diarrhea that may be bloody, and fever.

Storage and stability conditions of the medicinal product:

Store the dry powder at a temperature below 30°C, away from light and in the box.

Inject the resulting solution immediately after preparation.

Note: The color of the ready-to-inject solution is pale yellow to yellow.

Dosage forms and packaging:

Afazol® 250 mg powder for injection: Each vial contains 250 mg of cefazolin (as sodium salt) and is packaged in a box of 20 with a leaflet.

Afazol® 500 mg powder for injection: Each vial contains 500 mg of cefazolin (as sodium salt) and is packaged in a box of 20 with a leaflet.

Afazol® Powder for Injection 1 gram: Each vial contains 1000 mg of cefazolin (as sodium salt) and is packaged in a box of 20 with an instruction leaflet.