Indapamide (Indaxil)

Indoxil (indapamide)

Packaging

30 tablets

Type of drug

Oral

Dosage

1.5 mg

Indapamide is a diuretic with similar actions and uses to thiazide diuretics, although it does not contain the thiazide loop system. It is used in hypertension and is also used in patients with heart failure….
اینداکسیل

Indoxil® Indapamide

1.5 mg extended-release coated tablet

This medicine has been prescribed for your current condition, so do not use it in similar cases or recommend its use to others.

General instructions:

Before taking this medicine, consult your doctor in the following cases:

If you are allergic to this medicine or any other substance such as food, preservatives, dyes, etc.

If you have a history of any disease, especially kidney failure, liver diseases such as hepatic encephalopathy, hypokalemia, diabetes, heart diseases such as arrhythmia, gout, systemic lupus erythematosus and thyroid.

If you are taking any medication.

Use during pregnancy and lactation:

Indapamide should not be used during pregnancy and lactation except under the advice of a specialist.

Warnings:

Indapamide should be used with caution in people with a history of any heart disease, diabetes, kidney and liver diseases.

Indapamide is contraindicated in liver failure, kidney failure, hypokalemia, and sensitivity to this drug.

Indapamide interacts with many drugs, so if used simultaneously, the dose should be adjusted. These drugs include the following: Lithium (indapamide increases the effect of lithium), drugs used in arrhythmia such as amiodarone, quinidine, etc., neuroleptics such as antidepressants, antipsychotics, etc., gastrointestinal drugs such as cisapride, antibiotics such as erythromycin, nonsteroidal anti-inflammatory drugs such as ibuprofen, antihypertensive drugs, antifungal drugs such as amphotericin B, oral corticosteroids used in asthma and rheumatoid arthritis, muscle relaxants such as baclofen, various diuretics, metformin, calcium supplements, drugs that suppress the immune system and are used in organ transplantation such as cyclosporine and tacrolimus, and drugs used in Crohn’s disease such as tetracosactide.

Avoid taking indapamide if you have a history of allergy to sulfonamides.

Indapamide may be known as a doping drug in athletes, so consult your doctor if you are taking it.

Dosage:

The dosage of the drug is determined by the attending physician for each patient. However, the usual dosage of the drug is as follows.

Edema, hypertension:

1.5 mg daily (morning)

Note: Indapamide is not recommended for children.

How to take the drug:

Take the drug preferably in the morning and swallow it whole with water and avoid crushing or chewing.

If you take more than the prescribed amount, see a doctor.

If you forget a dose, take it as soon as you remember. If it is almost time for the next dose, skip that dose and do not double the dose.

Avoid stopping the drug suddenly.

Indapamide may cause dizziness and fatigue due to its blood pressure lowering effects, so avoid driving or doing things that require great care.

Side effects:

In addition to the desired therapeutic effects, any drug may also have some unwanted side effects. Inform your doctor if any of the following side effects occur.

Important side effects that require doctor’s notice if they occur:

Severe allergic reactions such as swelling of the face, tongue, lips, difficulty breathing, itching and skin rashes.

Less common side effects:

Angioedema, anemia, arrhythmia, dry mouth, fatigue, liver disorders, hyperkalemia, nausea and vomiting, pancreatitis, dizziness, blurred vision, hypotension, palpitations, flushing, confusion, headache, weakness, lethargy, muscle pain, anorexia nervosa, nocturia, polyuria, diplopia, electrolyte disorders, rash, itching and renal failure.

Rare side effects:

Hepatic encephalopathy, photosensitivity, QT prolongation, exacerbation of lupus and vasculitis.

Storage conditions:

Store the drug at a temperature below 30 degrees Celsius, away from light and moisture.

Avoid using expired medication.

Keep the drug out of the reach of children.

Dosage forms and packaging:

This drug is produced and distributed in the form of sustained-release coated tablets containing 1.5 mg of indapamide in boxes of 30 under the brand name Indoxil by Afa Chemie Pharmaceutical Company.

Indapamide is a diuretic with similar actions and uses to thiazide diuretics, although it does not contain the thiazide loop system. It is used in hypertension and is also used in patients with heart failure.

Similar to thiazide diuretics, it increases the secretion of sodium, chloride, and water by interfering with the movement of sodium ions from the proximal to the distal tubules.

The drug is readily and completely absorbed from the gastrointestinal tract. Its elimination is biphasic with a half-life of about 14 hours in the blood. Indapamide binds strongly to red blood cells and is extensively metabolized. About 60 to 70% of the administered dose is excreted in the urine, of which only 5 to 7% is excreted unchanged. About 16 to 23% of the administered dose is excreted in the feces.
Indapamide is not removed by hemodialysis, but it does not accumulate in people with renal impairment.

General Interactions:

– Binding to anion exchange resin or polymer
– Antihypertensive agent
– Potentiation of antiuricosuric effects
– Decreased renal perfusion or function
– Potentiation of hypercalcemia
– Potentiation of hyperglycemia
– Potentiation of hypokalemia
– Potentiation of hyponatremia
– Potentiation of photosensitivity

Class X interactions (avoidance):

Aminovulinic acid (systemic), bromperidol, fexinidazole, levosulpiride, promazine

Reduction in the effects of drugs by indapamide:

Antidiabetic drugs, methanamine

Reduction in the effects of indapamide by drugs:

Amphetamines, bile acid sequestrants, brigatinib, bromperidol, dexmethylphenidate, herbs (with hypertensive properties), methylphenidate, nonsteroidal anti-inflammatory drugs, opioid agonists, yohimbine

Increased effects of drugs by Indapamide:

Ajmaline, allopurinol, amifostine, aminolevulinic acid (topical and systemic), angiotensin-converting enzyme inhibitors, antipsychotics (second generation [atypical]), bromperidol, calcium salts, carbamazepine, cardiac glycosides, cyclophosphamide, diazoxide, dichlorphenamide, dofetilide, duloxetine, fexinidazole, blood pressure lowering drugs, ivabradine, levodopa-containing products, levosulpiride, lithium, mecamylamine, multivitamin/mineral (containing vitamins A, D, E, K, folate and iron), multivitamin/mineral (containing vitamins A, E and without iron), neuromuscular blocking agents (non-depolarizing), nitroprusside, nonsteroidal anti-inflammatory drugs, oxcarbazepine, pholcodine, porfimer, promazine, sodium Phosphates, topiramate, tormifen, verteporfin, vitamin D analogues

Increased effects of indapamide by drugs:

Alcohol (ethyl), alfuzosin, anticholinergics, barbiturates, benperidol, beta-2 agonists, brigatinib, brimonidine (topical), corticosteroids (oral and systemic inhalation), dexketoprofen, diacerein, diazoxide, herbs (with blood pressure-lowering properties), ipragliflozin, licorice, lormetazepam, molsidomine, multivitamin/fluoride (containing vitamins A, D and E), naftopidil, nicergoline, nicorandil, obinutuzumab, opioid agonists, pentoxifylline, phosphodiesterase 5 inhibitors, prostacyclin analogues, quinagolide, reboxetine, selective serotonin reuptake inhibitors

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