100 Pieces
Oral
300mg, 150mg
150 and 300 mg capsules
This medicine has been prescribed for your current condition. Therefore, do not use it in similar cases or recommend its use to others.
General instructions:
Before taking this medicine, consult your doctor in the following cases:
• In case of allergy to this medicine or other medicines or any other substance such as food, preservatives, dyes, etc.
• Patients with liver dysfunction, diabetes and porphyria
• Patients using antiviral drugs.
Use in pregnancy and lactation:
Rifampin should not be used during pregnancy and lactation unless advised by a specialist.
Warnings:
• Avoid drinking alcoholic beverages while taking rifampin.
• In patients with liver disorders, liver function should be monitored before treatment and every 2 to 4 weeks during treatment.
• Rifampin, through its enzyme-inducing effect, can increase the metabolism of adrenal hormones, thyroid hormones, and vitamin D.
• Patients taking systemic hormonal contraceptives are advised to use nonhormonal methods of contraception during rifampin therapy.
• Adults with tuberculosis treated with rifampin should have baseline measurements of liver enzymes, bilirubin, serum creatinine, and blood cell counts.
• Rifampin may cause a red coloration of urine, sweat, sputum, and tears, and the patient should be warned about this. Soft contact lenses may become permanently stained.
• Concomitant administration of antacids reduces the absorption of rifampin. Rifampin should be administered at least 1 hour before antacids.
• In patients taking anticoagulants and rifampin concomitantly, it is recommended to monitor prothrombin time daily or more frequently.
• Continuing to take rifampin after purpura appears can lead to cerebral hemorrhage and death.
• Rifampin accelerates the metabolism of the following drugs: anticonvulsants (such as phenytoin), antiarrhythmics, oral anticoagulants, antifungals (fluconazole, itraconazole, ketoconazole), beta-blockers, calcium channel blockers (diltiazem, nifedipine, verapamil), chloramphenicol, clarithromycin, corticosteroids, cyclosporine, cardiac glycosides, clofibrate, haloperidol, oral hypoglycemics (sulfonylureas), levothyroxine, methadone, opioid analgesics, tacrolimus, theophylline, tricyclic antidepressants (amitriptyline, nortriptyline), and zidovudine. Dosage adjustments of these drugs may be necessary when used concomitantly with rifampin.
Dosage:
The dosage of the drug is determined by the attending physician for each patient.
The dosage of rifampin can be given as a single or multiple doses per week, month, or even daily, depending on the type and severity of the disease in adults and children.
Note:
In the treatment of tuberculosis, leprosy, brucellosis, Legionnaires’ and serious staphylococcal infections, rifampin should be prescribed along with other effective drugs to prevent the emergence of resistant strains and to ensure effective treatment.
In patients with liver disorders, the daily dose should not exceed 8 mg per kilogram of body weight. Also, caution should be exercised in the use of rifampin in the elderly due to increased serum levels.
How to use the drug:
Skipping doses or not completing the full course of treatment reduces the effectiveness of treatment and increases the likelihood of bacterial resistance. For complete resolution of the infection, it is essential to comply with the duration of the treatment course, even if improvement is observed.
Rifampin should be taken 1 hour before or 2 hours after meals with a glass of water.
If you have stomach irritation, you can take the medicine with food.
If you take more than the prescribed amount, see a doctor. Symptoms of low blood pressure, swelling around the eyes or face, skin discoloration to red and orange, arrhythmia, and seizures can be signs of drug poisoning.
Side effects:
In addition to the desired therapeutic effects, every drug may have some unwanted side effects. If any of the following side effects occur, inform your doctor.
Important side effects that require doctor’s notice if they occur:
Sudden allergic reactions such as swelling of the face, tongue, shortness of breath, skin disorders, itching and hives
Common or very common side effects: nausea, vomiting, thrombocytopenia, headache, dizziness
Uncommon side effects: diarrhea, leukopenia
Uncommon side effects: diarrhea, leukopenia
Uncommon side effects with unknown incidence: disseminated intravascular coagulation, agranulocytosis, hemolytic anemia, anaphylactic reaction, glandular disorders, decreased appetite, discoloration of tears, sweat, urine, shortness of breath, hepatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, muscle weakness, kidney damage, edema, influenza, intracranial hemorrhage
Storage conditions:
• Store the dry product at a temperature below 30 degrees Celsius, away from light and moisture.
• Keep the medicine out of the reach of children.
• Avoid using expired medicine.
Dosage Forms and Packaging:
This drug is produced and supplied as 150 mg capsules containing 150 mg of rifampin in boxes of 100 and 300 mg capsules containing 300 mg of rifampin in boxes of 100 by Afashimi Pharmaceutical Company.
Product of Afashimi Pharmaceutical Company
Tehran, Km. 5, Fath Highway, Beginning of Noord Street, No. 13, Tel. 64059-021
BNF 2020
RIFADIN CAPSULES, Reference ID: 2862628
pdr.net
EMC RIFAMPICIN
Rifampin is used in combination with other anti-tuberculosis drugs in the treatment of this disease. It is also used in combination with other drugs in the treatment of acute staphylococcal infections and leprosy and atypical infections caused by Mycobacterium species, and in the prevention of penicillin-resistant meningococcal meningitis and Haemophilus influenzae infection.
Rifampin is a broad-spectrum bactericidal antibiotic that exerts its effect by inhibiting bacterial RNA.
This drug is well absorbed orally and is distributed in most tissues and body fluids after absorption. The serum concentration of the drug reaches its peak 2-4 years after oral administration. Rifampin is metabolized in the liver. The half-life of the drug is 3-5 hours, which decreases to 2-3 hours after repeated administration. The elimination of this drug is mainly through bile and feces, and the drug also enters the enterohepatic cycle. Approximately 6-15% of the drug is excreted unchanged and 15% as active metabolites in the urine.
General characteristics of interactions:
– OATP1B1 substrate
– P-gp substrate
– OATP1B1 inhibitor (strong)
– OATP1B3 inhibitor (strong)
– CYP1A2 inducer (strong)
– CYP2B6 inducer (strong)
– CYP2C8 inducer (strong)
– CYP2C9 inducer (strong)
– CYP2C19 inducer (strong)
– CYP2E1 inducer (strong)
– CYP3A4 inducer (strong)
– UGT1A1 inducer
– UGT1A3 inducer
– UGT1A9 inducer
– UGT2B4 inducer
– UGT2B7 inducer
– OATP1B1 inducer
– P-gp inducer
– Affected by delayed gastric emptying
– Change in normal gastrointestinal flora
– Intensification of anticoagulant effects
– Impaired immune response to bacterial agents
– Increased elimination of thyroid hormones from Body
Class X Interactions (Avoidance):
Abmaciclib, Alplicib, Hepatitis C Combinations, Apixaban, Apermilast, Aperpitant, Artemether, Asunaprevir, Atazanavir, Atovaquone, Avapritinib, Axitinib, B.C.G (Intravesical), Bedaquiline, Betrixaban, Bictegravir, Bortezomib, Bosutinib, Brigatinib, Capematinib, Cariprazine, Ceritinib, Cholera Vaccine, Cobistat, Cobimtinib, Copanlisib, Crizotinib, Dabigatran etexilate, Daclatasvir, Darulotamide, Darunavir, Dasabuvir, Deflazacort, Delamanid, Delavirdine, Dexlansoprazole, Dienogest, Diltiazem, Duravir, Doravirine, Doxorubicin (Conventional), Drondarone, Dolicib, Edoxaban, Elagolix/estradiol/norethindrone, elbasvir, alexacaftor, tezacaftor and ivacaftor, oliglustat, elvitegravir, encoratinib, enterotinib, erdaftinib, esomeprazole, etravirine, fedratinib, fimasartan, flibanserin, fosamprenavir, fosaprepitant, fosnetopitant, fostamatinib, gemigliptin, gilteritinib, glasdagib, glecaprevir and pibrentasvir, grazoprevir, ibrutinib, idelalisib, indinavir, irinotecan derivatives, isavuconazonium sulfate, istradifilin, itraconazole, ivabradine, ivacaftor, ivocidnib, ixazomib, lansoprazole, ledipasvir, lemboraxant, letermovir, lopinavir, lorlatinib, lumacaftor and Ivacaftor, Lomateprone, Lumefantrine, Lurasidone, Lerbinectide, Macimorlin, Macitentan, Midostaurin, Mifepristone, Mycophenolate, Naldemedine, Naloxone, Nelfinavir, Neratinib, Netopitant, Nifedipine, Nilotinib, Nimodipine, Nintedanib, Nisoldipine, Olaparib, Omeprazole, Ozanimod, Palbociclib, Panobinostat, Pazopanib, Pemigatinib, Pexidartinib, Pimavanserin, Piperaquine, Ponatinib, Praziquantel, Pertomanid, Quinine, Ranolazine, Regorafenib, Rufenacin, Ribociclib, Rilpivirine, Rimagpent, Ripertinib, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Sacituzumab Govitican, Saquinavir, Selpercatinib, Simeprevir, siponimod, sofosbuvir, sonegib, sorafenib, tasimelteon, tazmetostat, telithromycin, tenofovir alafenamide, tezacaftor and ivacaftor, ticagrelor, tipranavir, tofacitinib, toremifene, trabectedin, tocatinib, abrogpent, ulipristal, opadastinib, valbenazine, vandetanib, velpatasvir, ventocalx, vincristine (liposomal), vinflunine, vorapaxar, voriconazole, voxilaprevir, zanobrutinib, zolpidem
Rifampin increases the effects of drugs:
Asunaprevir, bosentan, clarithromycin, clopidogrel, cyclophosphamide, doxercalciferol, elagolix, eloxadoline, fexofenadine, fimasartan, fluvastatin, glecaprevir, and Pibrentasvir, ifosfamide, isoniazid, leflunomide, lopinavir, lorlatinib, pitavastatin, propofol, protionamide, rufenacin, romidepsin, saquinavir, thiotepa, vexilloprevir
Rifampin effects enhanced by drugs:
Antifungals (azole derivatives, systemic), cefazolin, cephalosporins (containing methylthiotetrazolium [NMTT] side chains), clarithromycin, delavirdine, elagolix/estradiol/norethindrone, eltrombopag, gemfibrozil, letermovir, pyrazinamide, triflunomide, voriconazole
Rifampin effects reduced by drugs:
Abmaciclib, abiraterone acetate, acalabrutinib, afatinib, agomelatine, alfentanil, aliskiren, alplisib, amiodarone, antifungals (Azole derivatives, systemic), Hepatitis C antiviral combination products, Apalutamide, Apixaban, Epremilast, Eprepitant, Aripiprazole, Aripiprazole Laroxil, Artemether, Asunaprevir, Ataloren, Atazanavir, Atorvastatin, Atovaquone, Avapritinib, Avatrombopag, Axitinib, Barbiturates, Bazedoxifene, B.C.G (intravesical), B.C.G vaccine (immunogenic), Bedaquiline, Benperidol, Beta-blockers, Benzhydrocodone, Betrixaban, Bictegravir, Bortezomib, Bosentan, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brivaracetam, Buprenorphine, Buprepion, Buspirone, Buprenorphine, Cabozatinib, Calcifediol, Calcium channel blockers, Canagliflozin, cannabidiol, marijuana (control), carbamazepine, cariprazine, carisoprodol, carvedilol, caspofungin, celecoxib, celiprolol, ceritinib, chloramphenicol (systemic), cholera vaccine, citalopram, cladribine, clarithromycin, clozapine, cobistat, cobimtinib, codeine, copanlisib, corticosteroids (systemic), crizotinib, cyclosporine (systemic), CYP3A4 substrates (high risk with inducers), dabigatran etexilate, dabrafenib, daclatasvir, dapsone (systemic), darolutamide, darunavir, dasabuvir, dasatinib, deferasirox, delamanid, delavirdine, dexamethasone (systemic), dexlansoprazole, diclofenac (systemic), dienogest, diethyl Acetylbestrol, diltiazem, disopyramide, dolutegravir, duravirine, doxorubicin (common), doxycycline, dronabinol, drondarone, dolicib, edoxaban, efavirenz, elbasvir, alexacaftor/tezacaftor/ivacaftor, oligoglustat, elvitegravir, encorafenib, enfortumab vedotin, enterictinib, enzalutamide, eravacycline, erdatinib, erlotinib, esomeprazole, estriol (systemic, topical), derivatives
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